(Reuters) - Sam Bradford tossed two touchdown passes as the St. Louis Rams beat Arizona 17-3 on Thursday, handing the Cardinals their first loss of the season.
The Cardinals, who had made their best start to a season in 38 years, arrived in St. Louis as one of the National Football League's three unbeaten teams but could manage just a 35-yard Jay Feely field goal against their West division rivals.
The Atlanta Falcons and Houston Texans are now the only teams without a loss. Both have a 4-0 record.
The Rams improved to a 3-2 record.
Bradford completed just 7-of-21 pass attempts for 141-yards but two of the completions were for touchdowns, including a fourth quarter 51-yarder to rookie Chris Givens that put the game out of reach.
A ferocious Rams defense made Kevin Kolb miserable, sacking the Arizona quarterback nine times. Kolb has now been sacked 17 times in two games.
Rams came out firing on all cylinders, Bradford going to the air completing three-of-four passes, including a 44-yarder to Danny Amendola, to set up a seven-yard strike to Lance Kendricks for the first half's only touchdown.
Amendola, who ranks second in the NFL in receptions and is Bradford's favorite target, left the game later with a suspected broken collar bone.
The Cardinals answered with a Feely field goal on their first possession but in the second quarter Rams rookie kicker Greg Zuerlein, who is a perfect 13-of-13 in field goal attempts, booted a 53-yarder to send the home team into the intermission up 10-3.
Neither Kolb nor Bradford, who threw a career worst 11 consecutive incompletions, were able to get their offences in gear until the final quarter.
Bradford ignited the crowd when spotted Givens sprinting down the sidelines and hit him with a pinpoint pass to take control of the contest.
The Rams defense did the rest, shutting down the Cardinals, who twice worked the ball down inside the St. Louis 15 but came away with no points both times.
(Reporting by Steve Keating in Toronto; Editing by Greg Stutchbury)
(c) Copyright Thomson Reuters 2012. Check for restrictions at: http://about.reuters.com/fulllegal.asp